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KMID : 0816119990020010059
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Korean Journal of Pediatric Gastroenterolology and Nutrition
1999 Volume.2 No. 1 p.59 ~ p.64
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Serum Fat Soluble Vitamins in Bile Duct Ligated Rats
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Sim Jay-Gun
O Myung-Ho
Kim Kee-Hyuck
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Abstract
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Purpose: The aims of this study are to measure the serum levels of fat soluble
vitamins (vitamin A and D) from bile duct ligated rats, and to evaluate the effect of
oral bile acids administration to facilitate absorption of fat soluble vitamins.
We measured serum ALT, total bilirubin, vitamin A, and vitamin D of
Sprague-Dawley rats 1 week before and 4 weeks after experimental bile duct ligation.
Rats were consisted with 3 groups. Group 2 had been find bile acids and group 3
ursodeoxycholic acid after operation for 4 weeks. Multi-vitamin was given to all groups.
Results: 1) Base line (mean value before duct ligation): ALT 74.2 IU, total bilirubin
0.26 ㎎/dL; vitamin D 13.01 ng/mL vitamin A 0.87 ㎍/mL, total bile acids 25.16 μ㏖/L.
2) Four weeks after ligation: ALT 100.7 IU, total bilirubin 2.58 ㎎/dL; vitamin D 7.89
ng/mL vitamin A 1.37 ㎍/mL, total bile acids 278.22 μ㏖/L. 3) 4 weeks after ligation,
each group (group 1, group 2 and group 3) showed vitamin D (7.62, 8.10 and 7.99)
ng/mL, vitamin A (1.68, 1.06 and 1.33) ㎍/mL, total bile acids (233.17, 345.80 and 268.57)
μ㏖/L, which were statistically not significant.
Conclusion: Serum level of vitamin A is increased after bile duct ligation although
vitamin D is decreased. Oral administration of bile acids does not affect the serum
levels of vitamin A and D in bile duct ligated rats.
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KEYWORD
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Cholestasis, Bile acids, Rat, Vitamin D,
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